Long-term use of sildenafil can lead to psychological dependence, and discontinuation of the medication can exacerbate erectile dysfunction. Furthermore, prolonged erections can damage the corpus cavernosum, causing erectile dysfunction. Long-term use of sildenafil can lead to endocrine disorders, affecting sperm quality and, in severe cases, fertility. Long-term use of sildenafil may lead to sensory abnormalities, depression, anxiety, dizziness, headache, and other symptoms. Long-term use of sildenafil citrate can cause excessive excitement in patients, accelerate blood circulation, leading to sudden increases or decreases in blood pressure. It may also induce cardiovascular diseases and, in severe cases, can lead to sudden death.